Fine gold threads leaning one way through deep blue water
SCIENCE

PDRN, made without animal-derived sources

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Advancing PDRN across five fields of human biology

Cardiology

Research

We are investigating PDRN in poor blood flow to the legs and feet.

ResearchPreclinicalClinicalApproved

Dermatology

Preclinical

We are investigating PDRN in burns, wounds that are slow to close, ageing skin and hair regrowth.

ResearchPreclinicalClinicalApproved

Orthopaedics

Research

We are investigating PDRN in cartilage, tendon and bone that heal slowly.

ResearchPreclinicalClinicalApproved

Gastroenterology

Research

We are investigating PDRN in the lining of the gut and the tissue of the gums.

ResearchPreclinicalClinicalApproved

Neurology

Research

We are investigating PDRN in nerves in the hands and limbs that recover slowly after injury.

ResearchPreclinicalClinicalApproved

Each programme is shown at the stage it has reached today. No Synthena PDRN programme has entered clinical trials, and no Synthena PDRN medicine has been approved for any indication.

Two fine metal needles on a white ground
OUR JOURNEY

The biology of PDRN

PDRN is DNA cut into short fragments, and every cell builds and mends its own DNA from the nucleotides those fragments supply. Published research links its effects to two routes, the nucleotide salvage pathway and the adenosine A2A receptor.

What changes when PDRN is produced without relying on animal-derived tissue? How does controlling the DNA fragments within a defined molecular-size range affect their consistency, biological activity, and therapeutic potential?

These are the kinds of questions our research is designed to answer, and to translate those findings into new medicines across five areas of human biology.

We expect what we find to change what a PDRN medicine can be.

OUR APPROACH

A focus on building blocks the body already uses

Every cell relies on nucleotides to build and repair its DNA. Research suggests that as PDRN is broken down, its components can enter nucleotide salvage pathways. We are developing PDRN without animal-derived starting material, with tight control over the length of the DNA fragments we produce.

Plant cells under the microscope, their walls stained teal and violet
A bright ragged edge between black and deep blue
THE MOLECULE

A narrower, defined range

Our target fragments are 20–80 base pairs, approximately 13–53 kilodaltons. PDRN described in the scientific literature commonly spans a much broader range.

Capped sample vials in an instrument tray, waiting to be measured
HOW IT IS MADE

From defined material to medicine

We control how our PDRN is made so that every batch is defined and consistent. We aim to carry that material from development toward medicines for patients.

Green and violet points of light on a dark ground
OUR STANDARD

Every number we keep travels with its date, its sample, its instrument and its operator.