Marshon Nguyen
Our founder presented the research behind Synthena at the Royal Society in London
The talk came eight months before the company was founded. This post records what was shown and what followed.
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Marshon Nguyen
We keep five things with every measurement
The date, the batch, the instrument, the operator and a retained sample stay with each result.
Victor Luu
We measure every batch by the length of its fragments
PDRN is described by the length of its fragments, and the field measures that length in more than one way.
Dewey Nguyen
Our target range is 20 to 80 base pairs
A defined range lets us compare one batch with the next.
Marshon Nguyen
We founded Synthena to study one substance, PDRN
Synthena makes PDRN without animal-derived sources and aims at a fragment-length range of 20 to 80 base pairs.
In the news
These items are press coverage of the fields we work in. Each one links to its source.
ScienceDaily
Scientists find a natural gut compound that helps heal the intestine
A compound made by gut bacteria from foods such as walnuts and berries may help repair the intestinal lining, per the source.
ScienceDaily
Nearly 10,000 patients reveal what works best for knee arthritis pain relief
An analysis across trials ranks knee braces, water-based therapy and regular exercise highest for pain and function, per the source.
ScienceDaily
Scientists discover a hidden immune signal that helps spinal cords regrow
In zebrafish, researchers find an immune signal that lets injured spinal cord fibres grow again, per the source.
Cosmetics Business
Same INCI, different origins: Why PDRN sourcing matters
A trade piece on why two ingredients with the same label name can differ by where the PDRN comes from, per the source.
ScienceDaily
Scientists discover why damaged nerves struggle to heal
A study in mice finds a protein that holds back the regrowth of injured nerve fibres, per the source.
BeautyMatter
Vegan PDRN Is Reshaping Regenerative Skincare as Biotech Alternatives Gain Momentum
A trade report on PDRN made without animal sources, from fermentation, microalgae and plants, and why demand for it is growing, per the source.
ScienceDaily
One injection reversed osteoarthritis in weeks
A Colorado team reports that a single injection restored arthritic joints in animal studies; human trials are expected, per the source.
ScienceDaily
New procedure delivers lasting knee arthritis pain relief without surgery
A minimally invasive treatment that blocks inflammation-driving blood vessels in the knee gave relief lasting at least a year, per the source.
ScienceDaily
Stanford scientists regrow lost cartilage and reverse arthritis in major breakthrough
Blocking an ageing-related protein restored cartilage in old mice, with similar signs in human cartilage samples, per the source.
ScienceDaily
Scientists “recharge” damaged nerves to ease chronic pain
Work in human tissue and mice tests whether restoring mitochondria in damaged nerve cells eases nerve pain, per the source.
ScienceDaily
Scientists discover simple way to relieve arthritis pain without pills or surgery
In a year-long trial, changing the angle of the foot while walking reduced knee pain as much as common medication, per the source.
ScienceDaily
MIT scientists discover amino acid that helps the gut heal itself
In mice, a diet rich in one amino acid helped stem cells rebuild damaged intestinal tissue, per the source.
ScienceDaily
Breakthrough drug reverses aging in skin and dramatically speeds healing
A study in mice reports that clearing aged cells from skin speeds the closing of wounds, per the source.
Harvard Health
Study questions the value of wrist splinting for carpal tunnel syndrome
A randomised trial found rigid splints and soft bandages gave similarly small improvements over 12 weeks, per the source.
Healthline
Is a cure for osteoarthritis on the horizon? New therapies show promise
Three approaches funded by ARPA-H, bone and cartilage regeneration and engineered living knee implants, aim to restore joint function rather than manage pain, per the source.
ScienceDaily
Simple therapies beat drugs for knee arthritis pain relief
A comparison of treatments for knee osteoarthritis finds non-drug therapies ahead for pain relief, per the source.
ScienceDaily
New oxygen gel could prevent amputation in diabetic wound patients
Researchers describe a gel that delivers oxygen into diabetic wounds that are slow to close, per the source.
ScienceDaily
Stanford scientists found a way to regrow cartilage and stop arthritis
A treatment that blocks an ageing-related protein helped prevent arthritis after knee injuries in mice, per the source.
Harvard Health
A new approach to peripheral artery disease
A trial in people with diabetes and poor circulation in the legs reports better walking ability on a newer class of medicine, per the source.
In the journals
These are journal papers on PDRN and the biology around it. Every title opens the paper's record.
Orthopaedic surgery
The Effect of Extracorporeal Shockwave Therapy in Tendinopathy: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Guo NY, Wang SQ, Liu W, Mao ZM, Wang JQ, Xu BB.
Journal of drugs in dermatology : JDD
Real-World Cases Using Phyto Polydeoxyribonucleotide (PDRN) Serum
Wu Y, Guénin S, Fung E, Brieva P, Li X, Lin LC, Raya CM, Rocha M, Sayed K, Schlesinger T, Sullivan J, et al.
Purinergic signalling
Interaction between purinergic signalling and purinergic modulators with skin wound repair effectors: a systematic review of preclinical in vivo models
Pelinsari SM, Goncalves RV, da Silva Mattosinhos P, Sarandy MM, Vilela EF, Novaes RD.
Frontiers in medicine
Case Report: Ultrasound-guided hydrodissection targeting the subsynovial connective tissue with dynamic ultrasound assessment in refractory carpal tunnel syndrome: a report of two cases
Lee D, Ahn T, Oh M, Lee J, Woo H, Kwon H, Park C, Kim CH, Ahn JY, Moon J, Lim DW.
Colloids and surfaces. B, Biointerfaces
Multifunctional therapeutic platform based on polydeoxyribonucleotide-loaded calcium carbonate particles for osteoarthritis management
Jung SY, Kim HJ, Kim SE, Park K.
International journal of molecular sciences
The Role of Polydeoxyribonucleotide as a Biotherapy for Musculoskeletal Disorders
Choi J, Yoo YM.
International journal of biological macromolecules
Surfactant-tailored alginate/pectin hydrogel beads delivering polydeoxyribonucleotide for inflammatory symptom alleviation and gut microbiota regulation
Zou Y, Liu X, Ding B, Chen Y, Qu W, Liu K, Zhang R, Yuan Y, Liu H, Dai W, Zhang H, Liu Q, Ren C.
Inflammatory bowel diseases
Effect of polydeoxyribonucleotide as a potential therapeutic agent to enhance the healing of Crohn's perianal fistula
Kim HK, Yoon YS, Lee JL, Park EJ, Kim MH, Kim YI, Kim CW, Park IJ, Lim SB, Yu CS.
Biomaterials science
Mechanical stress-driven conformational compaction of polydeoxyribonucleotide for enhanced transdermal regenerative therapy
Jeon S, Lee JI, Shim SB, Kim CH, Oh TJ, Gonçalves M, Kim JW.
Journal of functional biomaterials
Plant-Derived Polynucleotides/Polydeoxyribonucleotides in Skin Biomaterials: Delivery Platforms and Bioactivity Attribution
Kim HJ, Lee JW, Kim S, Son KH.
Cureus
Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials
Alhussain AM, Turki M Albusayys S, Alfhadi MA, Bu Mozah SA, AlShammari SSS, Alanazi HAM, Adil Alqazanli S, et al.
PloS one
Topical medium-length PDRN enhances dermal extracellular matrix repair in photodamaged skin via PI3K-Akt/TGF-β-regulated pathways
Ye R, Wang Q, Du L, Li L, Hu F.
Scientific Reports
Characterization of microbiome diversity and its association with healing outcomes in diabetic foot ulcer patients
How the wound microbiome relates to whether a diabetic foot ulcer heals. Not a PDRN paper; listed for its field.
Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
One-day rejuvenation: a preliminary case series of a multimodal protocol combining Q-switched 1064 nm laser, botulinum toxin, and laser-assisted delivery of PDRN and retinoids
Rodrigo Crisanto de Oliveira R.
Journal of clinical medicine
Hyaluronic Acid Fillers Versus Polynucleotides for Under-Eye Rejuvenation
Khan RS, Hafeez K.
Frontiers in medicine
Comparative evaluation of short vs. long needles in deep ultrasound-guided pharmacopuncture for acute low back pain: study protocol
Kim K, Lee YU, Kwon R, Chu H, Park S, Hong HJ, Lee Y, Kwon J, Song J, Kwon S, Leem J, Kim CH.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Global Trends and Evidence Evaluation: A Systematic Review of Polynucleotide and Polydeoxyribonucleotide Therapy in Dermatology
Kream EJ, Anooshiravani N, Hosking AM, Boen M, Fabi SG.
Transplantation proceedings
The Therapeutic Effect of Polydeoxyribonucleotide on Lung Ischemia-Reperfusion Injury
Sun F, Xu C.
Experimental and Molecular Medicine
Next-generation therapies for osteoarthritis: the evolving role of cell therapy products
A review of cell-based therapies for osteoarthritis and the trials ahead of them. Not a PDRN paper; listed for its field.
Talanta
SEC-MALS analysis of polydeoxyribonucleotides: Revealing product heterogeneity and enabling measurement standardization
Zhou B, Feng N, Nong X, Chen S, Li J, Zeng Z, Zhang W, Zhai X, Li L, Mi W, Hu Z.
Biomedicines
Polydeoxyribonucleotide Mitigates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through the PKA/CREB/NF-κB Signaling Pathway
Lee S, Hwang L, Kim SH, Lee SH, Han JH, Jeon JW, Shin HC, Ko IG.
International journal of molecular sciences
Comparative ESEM Characterization and Collagen-Related Tissue Responses to Commercial Injectable Bioregenerative Formulations in a Murine Model
Marcondes APSD, Barcellos FVC, Lacerda MRP, Costa ALO, Queiroz LDRP, Oliveira JR, Milo BG, da Costa TBCR, et al.
npj Biofilms and Microbiomes
Ulcerative colitis-driven gut dysbiosis exacerbates periodontal bone loss through the gut-oral axis
How gut inflammation in colitis worsens gum disease, in a mouse model. Not a PDRN paper; listed for its field.
Cureus
Polydeoxyribonucleotide (PDRN) in Post-procedure Recovery in Aesthetic Medicine: A Narrative Review
Flores Rodríguez JC, Toledo Avelar LE, Yi K, Merino Arellano R, Porras Zamora BM, Martínez LV.
International journal of molecular sciences
Synergistic Regenerative Strategies: Combining Polydeoxyribonucleotide with Biochemical and Physical Agents
Choi J, Jang SK, Lee D, Yoo YM.
Aesthetic surgery journal. Open forum
Comparative Effects of Injectable Biostimulatory Agents (Calcium Hydroxyapatite, New Cellular Treatment Factor, VAMP, and Human Exosomes) and Their Combination on Skin Regeneration
Adel N, Kolenda J, Hernández Gómez Crespo F, Zavala Resendiz GY, Jo YK, Thulesen IV, Saucillo JR.
Journal of orthopaedic surgery and research
Polydeoxyribonucleotide improves scar healing following limited scar resection for chronic Achilles tendon rupture in a rat model
Zhang H, Wu W, Su Y, Xiao C, Wang H, Cui F, Duan W, Meng X.
Scientific Reports
In vitro and in vivo evaluation of oleuropein loaded hyalurosomes for diabetic foot ulcer healing
A topical nanocarrier for diabetic wounds, tested in a rat model. Not a PDRN paper; listed for its field.
JAAD case reports
Safety and feasibility of the ISO-LPR protocol (isotretinoin, laser, and polydeoxyribonucleotide) in severe nodulocystic acne: A case report
Crisanto de Oliveira RR.
Biomacromolecules
Orthogonal Molecular Weight Analysis of Challenging Macromolecules Using MALS and Mass Photometry: Example of Polydeoxyribonucleotide
Chen S, Zhou B, Zhang W, Shang X, Nong X, Li J, Feng N, Zhai X, Jin S, Mi W, Hu Z.
BMC biotechnology
A novel method to encapsulate polydeoxyribonucleotides extracted from trout into exosomes and applications in skin recovery
Chang Y, Park JY, Hwang D, Kim MT, Yoon S, Cho SH.
Marine drugs
Polydeoxyribonucleotide (PDRN) Selectively Promotes Osteoblast Differentiation Without Affecting Osteoclastogenesis
Jeon Y, Heo E, Jin X, Lee DK, Che X, Kim HJ, Byun SH, Choi JY, Choi J, Oh J.
Marine drugs
Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract
Havas F, Krispin S, Cohen M, Attia-Vigneau J.
Orthopedic reviews
Advances in hyaluronic acid therapy for knee osteoarthritis: monotherapy and combination strategies: an evidenced based review
Cao KX, Tang HNA, Tran MH.
Scientific Reports
Topical treatment of diabetic foot ulcers using a novel quercetin-loaded hyaluosome gel nanoformulation
A quercetin gel for diabetic foot ulcers, preclinical. Not a PDRN paper; listed for its field.
Pharmaceuticals (Basel, Switzerland)
Guang Chenpi Extract as a Multifunctional Phytotherapeutic: Enhanced Effects with Ergothioneine and Polydeoxyribonucleotide on Redox Homeostasis and Tissue Resilience
Cen Z, Chen Z, Wang D, Zuo Y, Peng J, Chen J, Chen X.
Current issues in molecular biology
Oral and Intranasal Administration of Polydeoxyribonucleotide Isolated from Porphyra sp. Ameliorates Acute Lung Injury via Suppressing Proinflammatory Cytokine Production in Mice
Lee GY, Lee WS, Han J, Yoo YC.
Journal of cosmetic dermatology
New Cellular Treatment Factor (NCTF) and Polydeoxyribonucleotide (VAMP) Injections Enhance Skin Regeneration: Experimental and Histological Evidence
Adel N, Kolenda J.
Annals of plastic surgery
An Evidence-Based Assessment of Adjuvant Therapy in Autologous Fat Transfer: Ranking of the Potential Agents
Sarpong C, Oh I, Bouz A, Gupta S.
Journal of functional biomaterials
Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts
Hwang S, Park S, Lee JW, Park M, Nguyet LA, Hwang Y, Ahn K, Shin HY, Son KH.
Tissue engineering and regenerative medicine
Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications
Ku JK, Yun PY, Jeong YK.
Journal of oral & facial pain and headache
Efficacy of prolotherapy in temporomandibular joint disorders with hypertonic dextrose and Polydeoxyribonucleotide (PDRN)
Choi JW, Kim YK, Yun PY, Ku JK.
Macromolecular bioscience
Nanoformulated PDRN Improves Anti-Inflammatory and Wound Healing Activities
Kang JH, Jeon MJ, Kim SE, Hwang WK, Lee MY.
Yonsei medical journal
Efficacy of Submucosal Polydeoxyribonucleotide Injection after Impacted Mandibular Third Molar Extraction: A Randomized Controlled Trial
Kim HJ, Park SY, Kwon H, Fang Y, Kwon Y, Lee C.
Scientific Reports
Gene expression analysis of diabetic foot ulcers reveals the potential impact of Levofloxacin on wound healing
Gene expression in diabetic foot ulcers and an antibiotic's possible effect on healing. Not a PDRN paper; listed for its field.
Plastic and aesthetic nursing
Skin Tightening and Brightening: Vaginal Rejuvenation Using Polydioxanone (PDO) Threads and Polydeoxyribonucleotide (PDRN)
Delgado C.
International journal of molecular sciences
Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora
Bak SU, Jung MS, Kim DJ, Jin HU, Lee SY, An CE.
International journal of biological macromolecules
Multifunctional gelatin/phycocyanin composite hydrogel for infected wound therapy: pH-responsive drug release, antibacterial/antioxidant properties, and enhanced healing
Du Y, Nie Y, Zhang R, Liu G, Ren C, Li W, Tang Z.
Cellular and molecular biology (Noisy-le-Grand, France)
Skin regenerative potential of polydeoxyribonucleotide isolated from Saussurea involucrata
Kim DJ, Bak SU, Lee SY, Jung MS, Jin HU, An CE.
Clinical case reports
Refractory Alopecia Areata of the Beard: Novel Improvement Through Exosome Therapy With Signs of Hair Repigmentation
Shadid A, Nagshabandi KN, AlRuhaimi DK, Al-Omair A, Alsadhan A.
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Prolotherapy for temporomandibular joint disorders: an updated comprehensive review
Kim Y, Kim MJ, Yun PY, Ku JK.
Journal of cosmetic dermatology
Letter to the Editor: Use of PDRN and Nd:YAG Q-Switched 1064 nm Laser in the Management of Post-Inflammatory Hyperpigmentation Following Laser Hair Removal Complication
de Oliveira RRC.
International journal of molecular sciences
The Mitigating Effect and Mechanism of Polydeoxyribonucleotide Against Zoledronic Acid-Induced Growth Suppression of Human Gingival Fibroblasts
Pachhapure S, Shin YM, Kim DG, Choi DR, Yun JI, Kim JH, Jang BC.
Current issues in molecular biology
Modulating Skin Aging Molecular Targets and Longevity Drivers Through a Novel Natural Product: Rose-Derived Polydeoxyribonucleotide (Rose PDRN)
Cavagnino A, Azadiguian G, Breton L, Baraibar M, Black AF.
Cureus
Effect of Polynucleotides on Apex Lingual Regeneration After Amputation Due to a Car Accident: A Case Report
Saavedra P, Walker L, Arroyo P.
Eye & contact lens
Effect of Polydeoxyribonucleotide-Releasing Contact Lenses on Corneal Wound Healing
Ryu Y, Son HJ, Hwang JS, Oh SH, Lee JH, Kim GB, Shin YJ.
Clinics in orthopedic surgery
Atelocollagen Improves Bone-to-Tendon Interface Healing in a Rabbit Model of Chronic Rotator Cuff Tear Compared with Polydeoxyribonucleotide
Han J, Zhang ZF, Fang SY, Cui YM, Han SC.
Advanced materials (Deerfield Beach, Fla.)
Mesenchymal Stem Cell-Inspired Microneedle Platform for NIR-responsive Immunomodulation and Accelerated Chronic Wound Healing
Moon CH, Ko HG, Lee H, Bang S, Kang HS, Gwon JY, Seo JH, Lee N, Jeon SW, Kim YA, Yoon JS, Cha KY, Kang MH, et al.
Materials today. Bio
Tea-derived extracellular vesicles-mediated PDRN delivery activates cAMP-HIF-1α to restore intestinal homeostasis in inflammatory bowel disease
Cao T, Wan R, Li X, Hu X, Hu C, Liang Y, Deng M, Wang X, Yuan Z, Hu C.
Experimental and therapeutic medicine
Thermal-denatured PDRN exhibits increased in vitro pharmacological activities: A functional role of single-stranded DNA random coils
Lim HW, Huang YH, Baek HS, Kim HG, Kim KE, Lim CJ.
Journal of pharmacopuncture
Ultrasound-Guided Pharmacopuncture for Lateral Epicondylitis Initially Misdiagnosed Due to Incomplete Common Extensor Tendon Evaluation: a case report
Ahn T, Lee D, Moon J, Kim J, So Y, Cho HG, Ji S, Lee S, Oh M, Kim CH.
Journal of cosmetic dermatology
Letter to the Editor: Use of Polydeoxyribonucleotide, Retinoic Acid, and Laser in the Treatment of Postinflammatory Hyperpigmentation
de Oliveira RRC.
Pharmaceutics
Plasma-Engineered PDRN: Surface Charge Neutralization and Nanosizing Enhance Uptake and Regeneration Potential
Park SJ, Lee DH, Yoon KB, Kim A, Jung CY, Kim ST, Brito S, Bin BH.
Bioactive materials
Biomimetic aligned bacterial cellulose dressing containing polydeoxyribonucleotide for promoting wound healing
Zhu X, Liu F, Jin T, Chen H, Chung SM, Chen C, Lee IS.
European journal of pharmacology
Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates acetic acid-induced ulcerative colitis via modulating PI3K/Akt/VEGF signaling pathway
Lee J, Ko IG, Lee M, Hwang L, Kim SH, Jeon H, Shin HC, Lee S, Park SB, Choi HI, Joo KR, Cha JM, Shin HP, et al.
International journal of biological macromolecules
Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy
Liu Y, Hu W, Pei X, Zhu J, Meng H, Lyu Y, Qu Z.
Aesthetic plastic surgery
Air-Botulinum Neurotoxin and Polydeoxyribonucleotide Injections for Acne Scar Treatment
Park MH, Hwang SK, Hwang JK, Chua D, Yi KH.
npj Biofilms and Microbiomes
Periodontitis-associated Fusobacterium nucleatum promotes ulcerative colitis by ferroptosis-mediated gut barrier disruption
A gum-disease bacterium and its effect on colitis, in a mouse model. Not a PDRN paper; listed for its field.
Journal of proteome research
Elucidating Interactome Dynamics of the A2A Adenosine Receptor in the Presence of Polydeoxyribonucleotide
Lee W, Son A, Ji J, Han E, Cho JY, Kim JW, Kim YO, Kong HJ, Kim H.
International journal of biological macromolecules
Injectable in situ-forming silk fibroin-based hydrogel dressing with MXene/polydeoxyribonucleotide for wound protection and regeneration
Jang J, Chung HR, Lee SM, Lee EJ, Han CM.
Bioscience, biotechnology, and biochemistry
PDRN-like marker DNA shows skin beneficial properties through its single-stranded form
Lim HW, Huang YH, Baek HS, Kim HG, Kim KE, Lim CJ.
International journal of molecular sciences
Comparative Analysis of Melatonin and Polydeoxyribonucleotide: Possible Benefits of Co-Treatment Effects and Potential Synergistic Applicability
Jang SK, Choi J, Lim HW, Kim HG, Yoo YM.
Biochemical and biophysical research communications
Effects of polydeoxyribonucleotide derived from Gynostemma pentaphyllum callus on skin barrier function
Kim E, Choi S, Jang J, Shin HY, Ahn K, Kim SJ, Seo HH, Lee JH, Moh SH.
Orthopaedic journal of sports medicine
Therapeutic Effects of Polydeoxyribonucleotide and Atelocollagen into Achilles Tendon Injury in a Rat Model
Kim DS, Hui Won Y, Park SH, Seo JH, Ko MH, Kim GW.
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